Viral

Many viral ORFs encode a homolog to the cellular BCL-2 protein, as a result of horizontal (and also possibly lateral) gene transfer events. Several subclasses of viral BCL-2 homologs could be defined (representative proteins are listed below).

Adenoviridae

Gene nameProtein nameSynonymsPrimary functionBCL2DB acc.Reference
E1B19KE1B 19KE1BsinhibitorP03246Chiou et al., 1994

Asfarviridae

Gene nameProtein nameSynonymsPrimary functionBCL2DB acc.Reference
LMW5-HLLMW5-HLA179LinhibitorQ07819Neilan et al., 1993

Herpesviridae

Gene nameProtein nameSynonymsPrimary functionBCL2DB acc.Reference
A9A9-inhibitorO36423Ensser et al., 1997
BALF1BALF1-inhibitorP0CK58Marshall et al., 1999
BHRF1BHRF1-inhibitorP03182Pfitzner et al., 1987
V-BCL-2v-Bcl-2BoHV4inhibitorQ9WH78Bellows et al., 2000
M11M11gammaHV68 Bcl-2inhibitorP89884Virgin et al., 1997
ORF16ORF16KsBcl-2inhibitorQ76RI8Cheng et al., 1997
vNR13vNR13-inhibitorQ9DH00Aouacheria et al., 2003

Iridoviridae

Gene nameProtein nameSynonymsPrimary functionBCL2DB acc.Reference
070L070L-uncharacterizedQ677S5Zhang et al., 2004
097R097R-uncharacterizedQ6GZM8Tan et al., 2004
ORF115RORF115R-uncharacterizedQ5YFF0Song et al., 2004

Poxviridae

Gene nameProtein nameSynonymsPrimary functionBCL2DB acc.Reference
FPV039FPV039-inhibitorQ9J5G4Afonso et al., 2000
ORFV125ORFV125-inhibitorQ80G30Westphal et al., 2007

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