Cellular

The repertoire of cellular BCL-2 family proteins contains several groups of paralogs. Below are listed the well-annotated groups. All data listed in the tables refers to human proteins unless otherwise noted.

BCL-2-like

Gene nameProtein nameSynonymsPrimary functionBCL2DB acc.Reference
BCL-2Bcl-2-inhibitorP10415Tsujimoto et al.,1984
BCL2L1Bcl-xLBcl2l1inhibitorQ07817Boise et al., 1993
BCL2L2Bcl-wBcl2l2inhibitorQ92843Gibson et al., 1996
MCL-1Mcl-1Bcl2l3inhibitorQ07820Kozopas et al., 1993
BCL2L10Bcl2l10Bcl-B, Nrh, Nr-13, Diva, BooinhibitorQ9HD36Aouacheria et al., 2001
BCL2A1Bfl1Bcl2a1, Bcl2l5inhibitorQ16548Lin et al., 1993

BAX-like

Gene nameProtein nameSynonymsPrimary functionBCL2DB acc.Reference
BAXBaxBcl2l4promoterQ07812Oltvai et al., 1993
BAK1Bak1Bcl2l7promoterQ16611Chittenden et al., 1995
BOKBokBcl2l9, MtdpromoterQ9UMX3Inohara et al., 1998
BCL-WAVBcl-WAV-promoterD2Y5Q2Prudent et al., 2013

BID-like

Gene nameProtein nameSynonymsPrimary functionBCL2DB acc.Reference
BIDBidBidpromoterP55957Wang et al., 1996
BCL2L12Bcl2l12BprpromoterQ9HB09Scorilas et al., 2001
BCL2L13Bcl2l13Bcl-rambo, Mil1promoterQ9BXK5Kataoka et al., 2001
BCL2L14Bcl2l14Bcl-GpromoterQ9BZR8Guo et al., 2001
BCL2L15Bcl2l15BfkpromoterQ5TBC7Coultas et al., 2003

Other cellular homologs

Gene nameProtein nameSynonymsPrimary functionBCL2DB acc.Reference
ced-9CED-9-inhibitorP41958Hengartner et al., 1994
BuffyBUFFYDrob-2, dBorg-2inhibitorQ8T8Y5Brachmann et al., 2000
debclDebclDrob-1, dBorg-1, dBokpromoterQ9V9C8Colussi et al., 2000

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